TOPIC: Heard of PMMA (Medical Grade) OR Dr Casavantes? [PART 2]

@Dd71,
I agree with you there is a difference in penile injection and buttock injection in regard with the depth of the injected pmma. But I think what he ment you can get granulomas or lumps or prolonged redness of the skin if you inject pmma Intra-dermaly or superficially e.g nasolabial fold So as you inject more superficial in the skin you will have more body reaction than the deeper layers.
So I think what he ment comparing penile injection and buttock\'s injection with the more superficial plane e.g. facial wrinkles (here you can get 1:1000 a chance of a granuloma formation which can happen between 6 months -5years).
There is an article written by him about the correct technique of injecting pmma for correction of facial wrinkles and how to avoid any complications :-
escholarship.org/uc/item/45b4s0jb;jsessi...4647B34CB860F#page-1
There is another paper which we can have more information about pmma , how to avoid any complications and its treatment and there is a picture of a patient who had Arteplast (the bad pmma) in 1991 and post-injection pic. 15 years after fig. 6+7 :-
www.ncbi.nlm.nih.gov/pmc/articles/PMC2872008/
I just found out exactly what is the benefit of using bovine collagen (in Artecoll and Artefill) :-
Collagen is merely a carrier substance that prevents the microspheres from agglomerating (i.e. collagen prevent the formation of rounded mass of the beads) during tissue ingrowth.

EP when you say Dr C confirmed it can be performed, are you talking about Artefill ?

skatezy, that\'s probably easily answered, it\'s about a tenth of the cost !

Dd71 I have tried a temporary filler, It was macrolane which is basically a form of Hyaluronic Acid. The result was not good, I don\'t think you would like it.

For those of you who haven\'t seen this , I thought it was quite interestinghttp://blogs.poz.com/dave/archives/2008/12/my_new_old_face_1.html

Does anyone know if Dr. C has PMMA in his own body (not necessarily his penis). That would be a testament to his faith in the product. On his regular Dermatology site, it seems like it can be applied to just about anywhere...face, lips, to augment muscles like shoulders and chest and butt. Its even used to hide veins in the leg by building up surrounding tissue.

SO,
The reason I have mentioned that because my doctor from Brazil (Dr.Samy Passy - Metacrill) told me that time :- I could buy Metacrill from him directly or he could sell it to any doctors back home (so it looks so easy to buy Metacrill in Brazil and it is dangerous in the same time I think there are may be many non-professional persons in Brazil can get Metacrill easily and inject people with it and that\'s why you hear some bad results (e.g. lumps etc.), and I think Newplastic can be sold in the same way, I might be wrong. Or may be you just ask Dr.C. if he can give you a small ampule of Newplastic for any reason without telling him anything about our worries (I know you might not succeed).
Actually testing Newplastic or Metacrill is not so important for me, I dont need this test, ( as you know I had Artecoll in one side of my face for 15 yrs and Penile Metacrill for 3 yrs ) but I am interested of having PMMA injection in the future in the gap between the glans and the shaft . Till now I have no problem whats so ever from PMMA.
I just want to help and to give the guys esp. who are interested in penile PMMA but still they have the fear of PMMA migration how to prove that Newplastic is almost pure from any small irregular beads.

@smartman
I would not be alarmed if Dr. C\'s answer was \"no,\" because he could be violating any number of medical regulations/policies that would prevent giving out certain things/injectables/etc without proper reason/diagnosis/prescription, etc - however I don\'t know for certain what his answer would be and will ask.
I will be seeing them late July and will consult with them regarding the matter of New Plastic (and New Plastic vs other brands) during my 2nd appointment.

SO,
How about asking Wade or Dr.C. about our discussion that there are many guys in the forum would like to have Newplastic injection but they are worried about the possibility of migration of microspheres and there are some reports saying that Newplastic contains small or irregular beads , and they would like to have a small ampule of Newplastic (he might give us the ampule for free if he is interested to have more patients and he is convinced that Newplastic is almost pure) to be checked by (a non bias) US pathologist (SEM images) if his answer is NO, I will be very worried. What do you think ?

sparticus,
I am sure Artefill is more superior than the other products not only in regard of the microspheres but also the advantage of the carrier ( bovine collagen ) it helps in spreading the beads evenly till the new collagen take over.
I think in my opinion the best way to have the true answer for our Q. is if somebody from our forum can buy a small ampule of Newplastic ( I would love to do it just to have the proof but the problem I live far away from USA) and to be tested by a pathologist (not bias) ( and to do SEM images) looking for any small or irregular microspheres (purity of the beads) then we will be very satisfied and convinced after we see the result . So in my opinion by getting the answers from either Lemperle or Cohen wont help or convince most of us .

Smartman,

I believe directly contacting Dr. Cohen about his opinion would be very beneficial for the forum.

I\'ve taken this excerpt from one of the reports about migration:
Migration Studies and Histology of Injectable Microspheres of Different Sizes in Mice Gottfried Lemperle, M.D., Ph.D., Vera B. Morhenn, M.D., Vasumati Pestonjamasp, Ph.D., and Richard L. Gallo, M.D., Ph.D. San Diego, Calif.
Injectable Dermal Filler materials consist of either fluids, biological fragments, or suspensions of particles or microspheres. Particles and microspheres are said to 'migrate,' but migration can occur only when they are injected into blood vessels. To evaluate biocompatibility and transport, five nonresorbable polymethylmethacrylate microspheres of various sizes, suspended in different carriers, as well as resorbable polylactic acid and dextran microspheres were injected subcutaneously into mice. The five implantation sites were the right cheek, right axilla, right groin, urethra, and the right quadriceps muscle of the thigh. These sites were excised along with the local lymph nodes, lungs, liver, and spleen at 1, 3, 6, and 9 months after injection. Polymethylmethacrylate microspheres of 4 m and 8 m were phagocytosed but not transported to lymph nodes or distant organs. Larger microspheres of 20, 40, and 100 m were encapsulated by connective tissue, macrophages, and giant cells. Polylactic acid microspheres caused a mild inflammatory response and had disappeared at 6 months. Dextran microspheres caused a pronounced foreign-body reaction and were phagocytosed at 9 months. The extremely large carboncoated spheres of 200 to 500 m in diameter 'migrated' up to 1 cmfrom the implantation site. With the exception of an erroneous intravenous injection, no migration or transportation of any of the injected microspheres to lymph nodes or filter organs was seen. Obviously, the collagen glue released no microspheres. After subdermal injection, the collagen carrier substance kept the microspheres apart as a scaffold for tissue ingrowth, whereas all other carrier substances, such as gelatin, Hyaluronic Acid, or alginate, separated soon after injection, thereby causing agglomeration of the microspheres. (Plast. Reconstr. Surg. 113: 1380, 2004.)

even if there are small particles, he says they will not migrate, true ?

Prof.Lemperle replied today to my e-mails ( 5 e-mails) and I want you to share these information with me :-

1) Dr. Cohen is my friend: I sent you another paper with EMs I did, when I was still at Artes (it\'s great, they used all my descriptions but named me laboratory engineer, only) . There, you see the differences. However, since this report, Newplastic has been cleaned to a much better degree - at least what they showed to the Brazilian FDA. I still have some samples but no microscope any more to check for small particles.

2) Dr. Cohen never did any tests himself : he said what might have been hypothetized or may be logical. But there is no proof. On the other hand, the body takes care of soo many particles (think of the tar from cigarettes or the silicone particles from implants ..., and look at the Kupffer\' cells in the liver of old people : full of junk ! - So, these \"few\" small PMMA microspheres don\'t do any harm at all - if they were found in lymph nodes, liver or lung....
3) The only reason that I am preaching purity of PMMA for 10 years is the fact that these small particles are impregnated in the memory of the macrophages - and these or their heirs can be stimulated by systemic infections and cause foreign body granulomas years later !!!!

4) I have not tested the new Newplastic, which I got in December 2010 in Guadalajara .... So I cannot comment : if you know a pathologist , these samples could be washed and centrifuged and simply put on a glass slide to search for small particles - and make pictures for documentation ! -

5) I only found macrophages, who ate too many or too big microspheres - and couldn\'t move away from the site. In mice, I never found microspheres in lymph nodes or lungs... see this paper -http://cat.inist.fr/?aModele=afficheN&cpsidt=15662928
(( I think he gave us a great idea, if someone is worried about Newplastic he can buy the small bottle of Newplastic and try to find a pathologist in the US and to examine the beads looking for a small microspheres. How about this idea ? I think this is the best solution)).

@Dd71
Thanks for your concern. I\'m actually scrambling for a solution, and trying what I can when I can depending on product availability, geographical location and finances. One thing which brought me to change my move to board a plane to San Diego was the rather extravagant claims of sensible penile growth using a cocktail of Erection dysfunction injectibles, which I cannot confirm are accurate given they were sourced in a Toronto hair implant doctor\'s patent application. In any case I\'ll probably be trying a Quad mixture of penile injectibles on a daily basis to gain one to three hour erections during which I might do mid-level pumping under heat to then switch to low level pumping with a thermal shock of an ice pack to make the elastic gains to become lastingly plastic. If this procedure does work, especially associated with DHT and DMSO topical applications and bi-weekly injections of Gonadotropin, then I would possibly want to avoid PMMA prior to getting such gains? I might not succeed, one person testified to several years of TriMix injections with only half an Inch gain.
The reason I am now considering the Free Fat Transfer FFT procedure is because it would resorb over time, meaning that it could work as a stop gap measure to be less deficient with a lady used to basket ball players, while not causing any collagen resistance to ongoing or future PE gains by chemical or mechanical means. I understand that FFT is softer if not almost mushy, in comparison to PMMA, so I\'d probably want to get PMMA later. One other procedure I am contemplating is Dr Runels\' magic platelet plasma injection which takes your own blood and reinjects it after a chemically enhanced centrifuge procedure. No word yet on his experimental results...
I still may change my mind and hop over to see Dr C, it may depend on the price arrangements that can be made with the French doctor although it isn\'t in their habit of making concessions, charging by the Centimeter more than across the Atlantic by the Inch...
HC