TOPIC: Heard of PMMA (Medical Grade) OR Dr Casavantes? [PART 2]

I can see them. For some reason I could not some time earlier. May be a few kinks in the website which still needs to be run-in a little more?

i see them now, anybody hear back from dr.C about injecting temp. fillers or artefill?

I will try to get more information about the whole thing about PMMA and try to post everything in this forum (the good and the bad) somebody has asked me if Lemperle has any affiliation with Suneva Medical Inc.??
Lemperle has NO official affiliation with Suneva Medical Inc. and he has NO affiliation with any Brazilian products (e.g. Metacrill or Newplastic).
I have just received an e-mail from him:
To make it short : I had developed all three Arteplast (bad) Artecoll (first bad, then from 2006 on good) and ArteFill (best) . I funded Artes Medical and was fired after 6 years just before IPO and FDA approval in 2006. Then Artes went bankrupt in 2008 and sued me and my son Stefan for $ 30 Million damages... because we wanted to save our company from bankruptcy. Suneva took over this lawsuit and is still suing me : this is America !
I have nothing to do with all other products from Brazil, which were illegal copies of Arteplast.

Another e-mail :

You cannot compare silicone fluid with PMMA beads. PMMA does not migrate: even if phagocytosed, the macrophages cannot leave the location (too fat !) and remain in the implant.The only risk of both are foreign body granulomas , even after a few years. Theoretically, they are higher in NewPlastic than in ArteFill - but for one or another reason, they appear not to form deep under the skin, e.g. in a penis. As we know it from the skin ! And they can be treated effectivly withcortisone.So far, I would not be worrid about Newplastic in the penis .....until the first granuloma occurs - otherwise, I would have tried to stop Dr. Casavantes.
Another one :
no beads can migrate by themselves ! If they are phagocytosed, the macrophage cannot move. The only way to move to other organs is by swimming through open veins or venules during injection (we said in animal experiments with pigs where we found 40 micron beads in Lungs and lymph nodes but not 125 micron beads.
So, only later dislocation under the penile skin by pressure is possible during the first 3 weeks until they are fiully encapsulated.

Carboxy-cellulose is resorbed within 1-2 days, the present collagen in Artecoll or ArteFill within 3 - 5 days like gelatine (it is not optimally cross-linked ! - because the FDA would have asked for new trials...

Another one:
1. Necrosis cannot occur with cannulas since it is impossible to inject it into in artery (which has occurred with PMMAin Brazil several times in the facial artery with nasal Necrosis).
2. However, foreign body granulomas can occur after PMMA, especially when injected superficially into the dermis. This is not the case with cannulas ! Granulmas after all injectables occur in about 1:1000 in the face. In buttocks and penis I haven\'t heard or read about one case. As deeper from the skin injectables are deposited, as less they cause granulomas.
3. If inflammation or granulomas should occur, thet treatment of choice are Cortisone (Kenalog) injections : 2 -5 and they should be gone within 3 - 6 months.
4. Keloids raise from the dermis and have nothing to do with a foreign body reaction around PMMA microspheres, e.g if the PMMA or injectable is injected sub-dermally as in a penis. There is no proof or relation published within the last 20 years,
5. This is the best question : The cannula runs normally between the 2 fascia , that\'s where the skin moves over the corpora (and where also an implant is inserted. The early morning erections, however, let the corpora move forwards - and with this movement, the injected PMMA or whatever becomes automatically attached to the Dartos fascia, e.g. the skin.
6. I have tested NewPlastic - and it is almost pure , e.g. free of small PMMA microspheres, which might cause inflammation. The FDA approved ArteFill is absolutely pure and causes no granulomas anymore, however , it will be 10 or 20 times more expensive : 0.8 ml cost $ 450 to the doctor ! And you will need 10 -20 ml! -
7. Since the PMMA is attached to the skin , its Removal is rather difficult ! The excision can lead to Necrosis and skin defects and should be avoided ! Irregularities are in my eyes the only complication you may fear - and that is something you have to discuss with Dr. Casvantes : how often has he seen it - and how did he treat it ? Probably with more PMMA into the depressions. From all injectables today, PMMA is the safest (I say this not because I am biased) . There is Macrolane from Sweden on the European and Japanese and Korean market since 2010 , a high viscous Hyaluronic Acid like Restylane - however, it last for 1-1,5 years only - and is much more expensive than NewPlastic.
As far as I remember he mentioned before to me :
Low concentration of PMMA ----> less irregularitiesMore concentration of PMMA ----> more irregularities

supa wrote: Electronic microscopic images of Newplastic attached below (S. Cohen, Aesthetic Surgery Journal 2010 30:438).

How are we certain that the New Plastic photos you posted aren\'t from the pre-selection process?
And if they are post-selection process, then is it possible (depending on the frequency of irregular PMMA) one could conceivably find a similar \"snapshot\" among Artefill beads? I\'m wondering this because you see no such irregularities in the New Plastic photos in the link here ( www.biomedical.med.br/site/en/processo.asp and has noticeable differences in both smoothness and density than the pictures you provided (at least from what\'s discernible at those scales).
I should note (though the text is real small), it appears it has been zoomed 500x (correct me if I\'m mistaken), and the length unit is 100 micron.

I am also considering an adjunct to the DHT gel combined with DMSO: it is the gel form of TriMax which itself is an injectible combination of:
AlprostadilprostaglandinPapaverinevasodilatorPhentolaminealpha blocker
In gel form TriMax-Gel could be applied at the same time as Andractim DHT cream along with DMOS and this mixture would be especially capable of penetrating the shaft and glans throughout all of their structures. This might have an added benefit of placing the ingredients in the central soft tissue structure leading up to the glans, (which presumably wouldn\'t be reached by a shaft base injection into one of the two lateral veinous structures) ensuring a more coherent hormonal response throughout all bodies of this organ. This topical application of TriMax-Gel (with or without DHT) could presumably be done instead of or in addition to a Erectile Disfunction daily injection of TriMax injectible or another ED injection at the base... FWIW
HC

As I have stated in the past, please take anything Lemperle states with a grain of salt.
With that said, the studies posted here recently and others I posted in the past show the potential for PMMA, more specifically New Plastic, to migrate. If a substance can be phagocytized it can migrate.

If you don\'t think New Plastic was shown to be phagocytized please read ALL the posted studies on this forum and on forum 1.0.

@sparticus
What do you think about using ArteFill or Radiesse instead of New Plastic (ignoring the cost/impermanence factors)? Do you have the same concerns about these materials?

The report I have seen also mentions the formation of a thin capsule around the PMMA which should help to prevent migration.

Dd71, I agree with your plan to have the 10% concentration. It\'s what I would do too.

Electronic microscopic images of Artefill attached below (S. Cohen, Aesthetic Surgery Journal 2010 30:438).

Electronic microscopic images of Newplastic attached below (S. Cohen, Aesthetic Surgery Journal 2010 30:438).

Hi Guys,
I\'m calling forth your advice regarding the compatibility of PMMA injections with ulterior NATURAL growth enhancement. I am starting to undertake intensive hormonal treatments associated with directly injected vascular enhancers. This means that once I get my first session of PMMA and its associated collagen buildup my penis might still grow a good bit if the testimony seen below is valid.
phalloboards.websitetoolbox.com/post/sho...9224459&postcount=11
I am starting to take Chorionic Gonodotropin (better known as Pregnyl) at 3000 IU per week injected under the pelvic skin. I plan to also take a strong Erectile Dysfunction injection daily directly into the penis - ouch! Add to that DHT with enhanced penetration using DMSO as a carrier and there is a small chance of actually experiencing noteworthy penis growth by chemical means. Wouldn\'t the collagen strands generated by PMMA, with their harder buidup, tend to resist growth pressure not so much longitudinally but mostly of girth? The last thing I want is for PMMA induced collagen layers to PREVENT harmonious penis englargement and reduce my girth potential ? ! ?
HC

Forum members with medical/chemistry background please look at the legends of the EM images I have attached in previous posts.I have noticed the following:The Artefill beads in picture A of the first attachment look bigger than the Newplastic beads in picture B of the second attachment. But if you read the legend at the bottom of the pictures, you notice that the picture A of the first attachment (Artefill) has been magnified 400 times whilst the picture A of the second attachment (Newplastic) has been magnified 250 times. Furthermore, the length unit in Artefill picture A is 100 micron whereas the length unit in Newplastic picture A is 200 micron. They also differ in length between them in the legend (check this with a ruler), however the width of the two pictures is the same. You need to be a bit cautious and reproportion in order to compare.