itgoesthud wrote:
Skeptical_One wrote: By 4-6 weeks, vasculature should already be established in the Alloderm, and this will continue to grow. The Alloderm is slowly replaced by the body's own collagen and becomes "part of the body" and rejection will no longer be a concern.
It almost sounds like you end up with a massive network of blood vessels that builds within the dermal graft, eventually replacing the graft tissue with collagen, and removing the graft material via the newly-established vasculature.
Skeptical_One wrote: Bellafill is considered to be a permanent filler, although some reduction can occur over the years and sometimes it is necessary to do touch-up injections.
This is also interesting. What reduces, the carrier gel or the spheres? As long as the spheres are there shouldn't the body keep replacing any lost collagen if any is metabolized? Are we losing spheres to the lymphatic system? In the shaft we expect the gel to dissipate, spheres stay behind and get encapsulated by collagen like a pearl in an oyster. But the spheres stay there until you die, no? I guess I don't understand the mechanism by which it reduces - my worry is somehow the microspheres are leaving the site and entering the bloodstream.
To be frank I'm not sure of his comments regarding "
some reduction over the years, but my guess would be either (1) atrophy/shrinkage some men experience with age and/or lifestyle habits over years, which may also impact the collagen or (2) speculation based on Suneva's (Bellafill's manufacturer) projection of a 5-Year lifespan of PMMA.
And as for Suneva's claims, I'm not sure why or what they are thinking but I have a few plausible scenarios:
(1) They had 5 years of data when obtaining FDA Clearance, so they could guarantee it for at least 5 years.
-or-
(2) It's a disingenuous marketing pitch -- a lot of Cosmetic Clinics aren't overly fond of permanent fillers and so if you advertise it as long-lasting instead, it may become more appealing to Doctors who would otherwise be on the fence.
-or-
(3) Perhaps it isn't entirely permanent, but so long-lasting that for most people it's effectively permanent (in other words, I'm 12 years post-op with no notable loss in size from PMMA, but maybe will notice some loss at the 15 or 20 year marker?). By all accounts, it is seemingly permanent.
The microspheres in Bellafill are pretty much in the same size range as Linnea Safe (which is crucial), the only notable difference being carrier. On paper, Bellafill should absolutely be permanent, and I have yet to hear a scientific/medical claim that would suggest otherwise.
If you guys want to continue discussing the merits of Bellafill in conjunction with Alloderm or Surgimend, I recommend creating a new topic. I don't mind the discussion of course, but I also don't want to hijack Skiman's thread either. Thanks