Sorry... I've been distracted since I took the role of patient coordinator for
Avanti Derma while working from home for almost three months. I took full responsibility for office communication, and it has been a great experience to participate in the dynamics of patient recruiting.
PMMA is an inert substance. It doesn't trigger any allergic reaction in our system.
Reported cases of "allergy" to
PMMA are in reality:
1) Allergy to bovine collagen, which is found in the formula of Bellafil, the only
PMMA-based filler available in the US. The Brazilian brands of
PMMA are suspended in another inert substance, a water-based gel knows as carboxymethylcellulose. There are no cases of allergy in patients who receive a mixture of
PMMA/Carboxymethylcellulose.
2) Misdiagnosed allergy: this is the typical confusion between an inactive
Nodule (a simple excess of
PMMA that creates a nod of microspheres and collagen), and a true granuloma, which is a cellular-based immune response.
I haven't documented cases of patients developing an allergy to
PMMA over the years, but I have published that over 50% of patients have some level of imperfections, mostly inactive, passive nodules that don't trigger an immune response.
DrC