The hardening is fibrosis, and it\'s reported in the literature with this same filler when used in the face (belafill / artefill) that can happen over time - even 5 years later. Its under 5% - or at least, they claim it is. DMSO seems to have encouraged more water to surround the area so it feels fuller and softer, but when you stop using it, the hardness comes back. As a test, I put some of the excised
Nodule in 99% dmso in a petri dish overnight and it did not affect any of the tissue. Some air bubbles came to the top, but that was it. The hardening doesn\'t come in cycles. It was a slow process over time that took 6+ months, though some was quite hard right away. The squishier
PMMA (the normal stuff I had from R1 and R2) hardened now. I had a
Kenalog-40 + 5-fu shot in one of the semi-hard (not rock hard) nodules and that seemed to help soften it after 1 week. (the rock hard ones are almost impossible to inject into). The difficult problem is that these nodules are softer on the inside and have a very hard shell on the outside, and you don\'t want the
Kenalog going on the outside because it can
Atrophy the penile skin. Ideally, the
Kenalog should be put inside the
Nodule. The hard shell on the outside is what you feel...and even shrinking the nodules down can still leave weird hard lumps inside of your penis, albeit a little smaller.