hi guys just thought i\'d chime in to clarify some bits and bobs
eqstudent wrote: One important note, the scaffold material (PLGA, ePTFE, ') is more likely to cause a foreign body reaction than Alloderm,
in my understanding this foreign body reaction is what causes new tissue and blood pathways to grow within any matrix
eqstudent wrote: remember Alloderm is an Acellular dermal matrix.
again in my understanding this is a good thing when compared to implanting someone elses unprepared cellular tissue which could be rejected but irrelevant as a negative when compared with other acellular matrixes such as prepared pig dermis or synthetic scaffolds
When compared to synthetic (also obviously acellular) scaffolds such as PLGA I believe it is at a disadvantage for the following reason
According to my understanding and experience, the PLGA scaffold dissolves completely with only the new tissue remaining. (Unfortunately there is little to no gain and no guarantee of consistent tissue creation). With the alloderm or any other material that is not guaranteed to completely absorb there are dangers. Not only can the graft contract in unusual ways, as Hoddle has mentioned, it is grafted to the fascias and can cause limitations in
Erection length and twisted appearances not to mention blood flow issues.The major danger however is if new vessels are not grown through the graft quickly, which is more difficult with thicker or multiple sheets, and the graft does not either \"take\" (ie become cellulariesed) or completely dissolve, the body is left with this acellular material that is now prone to harbouring infections. The body has less chance of fighting the infection because of the very fact that the graft is acellular and porous
eqstudent wrote: Also the task of combining one's cells with the scaffold material and ensuring survival and growth is daunting.
Daunting, yes, but applies to alloderm too.
eqstudent wrote: I am very confident that if you ask 100 surgeons today on the safety of Alloderm vs. Scaffolds all 100 would pick Alloderm. Now in 7 to 10 years that may change.
Not sure if this is useful...better to ask 100 urologists. Also find out how many doctors have had to take out alloderm grafts.
Urologist Dr Gary Alter can give some good advice regarding this.
eqstudent wrote: As the CMO of the firm where I work said about the emerging scaffolding opportunity 'let them continue to experiment on people in Eastern Europe and the Far East where no one seems to care'.
Your CMO sounds unethical at best and it also seems that the company you work for are not going to win any awards for pioneering efforts or breakthroughs any time soon . Perovic and his team were world renowned. At least in the UK all the top urologists I had consulted respected the work that the Serbian team did. Also I doubt any doctor anywhere really cares about us the way we are supposed to care for ourselves. There is limited sympathy when things go wrong especially with penis surgery whether in serbia, uk, thailand, us or mexico
Even though the surgery didn\'t work in terms of gains, I am glad I was left with nothing rather than a dodgy alloderm graft years later. Being
Circumcised is a major drag too but that would have happened with any surgery regardless.
I would not recommend either procedure and in hindsight would never recommend anyone taking a scalpel near their penis unless absolutely required.
However, even though no urologists are going to appreciate anyone inserting
PMMA in their penis, my interest is still piqued and I enjoy reading the studies that you gopher out so keep it up please. More information both negative and positive regarding the procedure is better and thanks to all.
(disclaimer: just an average joe with no medical background yada yada, read as opinion only)