This is a question frequently arises in consultations: Can patients who have had a satisfying experience with HA fillers transition to polymethyl methacrylate (PMMA) for a more enduring result?
The most common scenario is : a patient tries HA and is happy with the results and now they seek a more permanent option with PMMA. Is this transition feasible? The short answer is yes.
Some doctors suggest it is problematic and want you to dissolve all your HA before proceeding with PMMA. Their concerns are as follows:
1. Risk of Complications:
They argue that the presence of HA might interfere with the PMMA integration process, potentially leading to unevenness, granulomas (inflammatory reactions), or even more severe complications due to the unpredictable interactions between the two substances.
Response:
There is no inherent reaction between HA and PMMA that would preclude their sequential use. It is important to remember that hyaluronic acid is a naturally occurring in the skin's dermal matrix. When PMMA fillers are injected into the dermal or subdermal layers where natural HA resides, they typically do not provoke adverse reactions. This is because PMMA microspheres are designed to be biocompatible and, when used correctly, should not interact negatively with HA or other dermal constituents. Injecting PMMA in areas previously treated with HA-based fillers should theoretically be as safe as injecting it into the untreated dermis, which already contains HA. The key is the technique used during the procedure:
2. Unpredictable Outcomes:
The concern is that the temporary HA filler could alter how the PMMA settles, potentially leading to asymmetry or dissatisfaction with the aesthetic outcome.
Response:
The injector must employ precision when injecting PMMA to ensure the microspheres are evenly distributed and to avoid the formation of granulomas or nodules just as they would when injecting into a penis with no HA. PMMA should be carefully injected to avoid disrupting the uniformity created by the HA fillers
4. Gradual Transition:
Some practitioners advocate for a gradual transition from HA to PMMA, allowing the HA to partially metabolize naturally over time. This approach can provide a smoother transition and reduce the risk of complications associated with immediate layering.
Response:
I fully agree with this. If you are at a size, you are happy with why not just slowly replace your HA with PMMA over time. It allows you to have more precise placement of the PMMA.
5. Time Interval: It's sometimes advised to allow sometime between the HA filler dissipation and the PMMA injections. This gap can help the practitioner assess the natural anatomy of the penis without the influence of the HA filler.
Response:
This not necessary if the original HA filler was well placed and has been well integrated into the tissue. This might be desired however if the original HA was poorly placed.
Why Not Dissolve the Existing HA?
Dissolving HA is not cheap, hyaluronidase is expensive, and a significant amount is needed for full reversal. Why incur this expense if it is not needed. Also why reverse the gains that you have already paid for? Dissolving the existing HA just seems like an unnecessary expense.
Conclusion
From a biochemical standpoint, there's no reason to expect that PMMA cannot be safely injected into areas where HA fillers have been previously placed.
Through my clinical experience, I have found that both hyaluronic acid (HA) and polymethylmethacrylate (PMMA) fillers can be safely employed for penile augmentation, whether they are used together or in a sequential approach, to meet the preferences and objectives of my patients.
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