On 17th of April 2020 in France, a French dermatologist treating a woman for facial nodules following Ellansé injection, declared getting Granuloma resorbed after Methotrexate administration.
This recent discovery has not been explained by any study yet. But we do know that Methotrexate inhibits folic acid secretion, involved in DNA secretion. This effect had mad Methotrexate an option for cancer therapy.
Granulomas following Ellansé injections would best be described by forum veteran members as our own tissue excess. As our own tissue are produced from our own DNA, inhibiting folic acid and thus inhibiting DNA seems perfectly logic.
From my personal point of view I consider Methotrexate effect on Ellansé similar to what we could get on PMME. Both are collagene stimulators and in both cases nodules are formed the same way. No matter if you considere Ellansé a semi permanent option, the principle is the same.
I also see in this molecule a possible preventive treatment on PMME / Ellansé Round 2 and subsequent
Inexperienced public could see as a side effect the possible vanishing of obtained gains. But a "CTRL + Z" button for Ellansé and PMME is what generation of Phallo Board members have been looking for.
This discovery needs more investigation. Any research, experience, feedback or comment on this subject will be greatly appreciated.
These are the kind of forum contributions/postings (that aren't progress reports) that are 5-star, sharing scientific & medical developments that could find its application(s) in Phalloplasty. Very interesting information, I'll be curious to ask Sponsors who employ Ellanse their thoughts.
About a week or two after I had Ellanse I had a small blister like nodule form. It was in the sensitive area under the circ scar. That area got a bit red during the procedure, but the "blister" formed a week or so later. It hurt when sqeezed, kind of a sting just like a blister. Doctor Carney said it was a granuloma and removed it with a small incision. It was not an issue.
I also had two other "nodules" form. These were small rubbery nodules, which I thought was fibrosis or scar tissue that formed during the inflammation process. No amount of massaging helped. They are not painful at all. You can feel both when flaccid, one only barely when erect (the other one is deeper).
I find the terminology confusing. I understand that there are inflammatory and noninflammatory nodules, and the inflammatory type are red, inflammed or painful. The first nodule I mentioned was definitely inflammatory, the other two were noninflammatory. Dr. Solomon called granulomas "balls of scar tissue" in his post on dermal fillers. That sounds exactly like the second two nodules.
One thing is clear, both types were "delayed onset nodules", and this is an article that discusses them:
"Lumps, masses, nodules, regions of induration, delayed hypersensitivity reactions, biofilms, sterile abscesses and granulomas are all terms used to describe a delayed onset nodule."
Sounds like there are several types. I still don't know how to characterize the two rubbery nodules I have. They are not clumps of Ellanse, they definitely formed during the inflammation process. Doctor Carney only classified the first one as a granuloma, but from Dr. Solomon's comment it sounds like they are.
I routinely use 5 Fluro Uracil (5FU) mixed with steroid (Triamcinolone) dealing with keloid scars and also nodules and granuloma from injectable fillers including Ellanse. It is also an anti-cancer drug. I have heard of Methotrexate being used for granuloma but never considered it myself as it is used as a cancer drug and for rheumatoid arthritis. But this is at the RA dose, which is much lower. I dont know if there are any limitations on prescribing it here in Australia and will look into it. I have not been able to get the full article yet and will keep try for that too.
I found the article and Google translated it out of French. Really interesting. Simple oral medication, but for 12 months. And being a medication used to treat cancer, but at this dose arthritis, may scar people off. Important article though.