TOPIC: Topical Androgen Receptors?

Not sure if this is the right forum. I am completely new here and have been doing lots of research into various methods of increasing size.

I've been studying the mechanisms that cause the initial growth and it seems it all comes down to a finite resource of androgen receptors within the tissue of the penis.

I initially targeted DHT as my wonder molecule but that was before I understood the actual mechanism by which DHT can trigger growth.

I am not biologist, but have studied in great detail and read multiple studies which I will try to find links to that suggest that with age, the presence of androgen receptors within the Foreskin of the test subjects, dropped off sharply after the age of around 20 (the same age at which growth stops).
Androgen receptors are teh mechanism by which testosterone and DHT can cause expression of primary sexual characteristics within the cells of the tissues themselves.
I doubt it is as simple as just this mechanism to trigger growth, but surely finding a way to increase androgen receptors within the tissue of the penis would be the smoking gun of penis enlargement. Androgen receptor is a molecule and as such there should be a way to transport into the 'intracellular' spaces that it would be found naturally. Such a topical alcohol gel, like with testogel.
Combine this with natural T production by doing strenuous weights and sprinting and you have a pretty decent way of restarting growth.

Does any here have more knowledge on this?

Or if anyone knew of any research already going into this I would be very interested to hear it.

There is another study where they managed to sythesize the molecule via gene splicing into a fungus but I seem to remember it was part of research into prostate cancer.

Obviously I am aware of the link between Testosterone/Androgens and Prostate cancer but for the sake of this discussion I am only concentrating on the exact mechanism that causes growth of the penis.

I'm surprised no one is interested in this as a concept.

What I am proposing is to try to create a cream composed of the NR3C4 molecule that can be applied to the penis to try to increase the local presence of this molecule within the tissues of the penis. Technically the molecule should be able migrate into the cell and undergo the usual processes which cause it to bind with dht and migrate into the nucleus to trigger transcription of the correct genes that lead to growth and maturation.

Dependant on whether it is possible to migrate into the cell already bonded with dht, a super molecule could be produced which would already have this combination which would increase the effectiveness.

I imagine that getting a pharmaceutical company to produce a specific biological molecule would be expensive and probably contravene all kinds of medical laws.

Perhaps somewhere like china would be a good place to start as they have the resources and will to do something like this.

If it worked it would be as simple as daily application of a cream which should cause natural and controlled growth. The research would not be very difficult and could probably be tested on mice. Although the thought of Chinese scientists creating monster Cock mice is definitely in the realms of unusual lol.

The reason for me posting this is that I would imagine that a group of people with similar goals and more knowledge would come together to discuss and possibly lead to a more speedy conclusion. Do we have any pharmacists use this board? Any biologists? Am I totally on the wrong path with this idea?

I'm surprised no one is interested in this as a concept.

Well, man, to be honest it's very hard to debate about your idea.
It's pretty much thin air when you don't have a scientific background but only put there some vague ideas.
Do you realize how technically hard is what you are suggesting to do?
Where are we going to find these "chinese labs" that would start a multiple years project about this?
Who is going to fund it?
What happens if it fails? (which can very much happen)
I'm sorry but hardly somebody is going to embark in this project, hope you don't take offense but I think that's the current situation.

Sure, one day men will be able to manipulate genetic expression with exceptional accuracy, and maybe Penis Enlargment will be targeted (though not on high priority for sure).
But I doubt it will happen in our life-span and even more in our sex-life span.

Right now our best call is to:
- put our penis in a Hanger/extender for those who want length
- save money for a filler for those who want Girth

My 2 cents.
Good luck if you pursue this ambitious project.

Gg82 wrote: I'm surprised no one is interested in this as a concept.

Well, man, to be honest it's very hard to debate about your idea.
It's pretty much thin air when you don't have a scientific background but only put there some vague ideas.
Do you realize how technically hard is what you are suggesting to do?
Where are we going to find these "chinese labs" that would start a multiple years project about this?
Who is going to fund it?
What happens if it fails? (which can very much happen)
I'm sorry but hardly somebody is going to embark in this project, hope you don't take offense but I think that's the current situation.

Sure, one day men will be able to manipulate genetic expression with exceptional accuracy, and maybe Penis Enlargment will be targeted (though not on high priority for sure).
But I doubt it will happen in our life-span and even more in our sex-life span.

Right now our best call is to:
- put our penis in a Hanger/extender for those who want length
- save money for a filler for those who want Girth

My 2 cents.
Good luck if you pursue this ambitious project.

Cheers dude yes I am using an extender and going to go for Ellanse one day when I have money.

I literally just found a company online by accident, that is selling the exact protein that I need. The crazy thing is it ships from taiwan.

Very pricey but I'm certainly going to look ok into it further. I just really need to get in touch with someone who understands the biochemistry a little better than me. I don't even know if the protein will get into the cells, but it should since it is designed to do so in the body.

danbionic wrote: Not sure if this is the right forum. I am completely new here and have been doing lots of research into various methods of increasing size.

@danbionic

Check your PM inbox. I will be waiting for answer. Thanks.

it would be a dream, but I personally doubt that something topic could promote any kind of growth

tiritera wrote: it would be a dream, but I personally doubt that something topic could promote any kind of growth

If we found the right combination of hormones and receptors and IF they could be made to absorb into the skin then yes it should be possible to cause the necessary effects. Topical application is known to increase the local presence of hormones at the same time as increasing the systemic.

The key is finding the right combinations. I am almost certain this will involve testosterone, dht, alpha reductase and of course the human androgen receptor. I personally think the androgen receptor is the most important part of the equation because of the evidence that they sharply decrease after the age of 20 within the tissues of the penis.

This is the exact age when growth stops.

i m in china ,and i 19years
i need your help to tell me how can i get bigger Dick

chenxiao wrote: i m in china ,and i 19years
i need your help to tell me how can i get bigger Dick

You're still young and a "big Dick" is overrated. Focus on your health, education, and career. Focus more on having your own sense of style and sense of humor. Don't bother with surgery right now.

This is off-topic but I figure English isn't your 1st, or even 2nd language so I wont penalize you for it, just be mindful if you choose to post again.

ok,my english not good but i want a way to get bigger , so i want to make more friend in this from

chenxiao wrote: ok,my english not good but i want a way to get bigger , so i want to make more friend in this from

Please DO NOT post off-topic in this thread. Make your own thread and ask your questions. Stop spamming in this specific thread. This thread is not about personal questions.

danbionic wrote: If we found the right combination of hormones and receptors and IF they could be made to absorb into the skin then yes it should be possible to cause the necessary effects. Topical application is known to increase the local presence of hormones at the same time as increasing the systemic.

The key is finding the right combinations. I am almost certain this will involve testosterone, dht, alpha reductase and of course the human androgen receptor. I personally think the androgen receptor is the most important part of the equation because of the evidence that they sharply decrease after the age of 20 within the tissues of the penis.

This is the exact age when growth stops.

@danbionic
Haven't seen you for a while. Are you still there?