In all my years reviewing every bit of literature that has come through the
PhalloBoards (and elsewhere) as it pertains to these procedures, I haven't found anything alarming with respect to penile enhancement +
PMMA.
The only (hardly) note-worthy matter is when men have had large volumes (we're talking hundreds and hundreds of cc's/mL's) injected intramuscularly that later go on to deal with rare systemic granuloma issues (which in turn can cause other & lesser known rare issues to occur). It should be noted these studies involved silicone oil, but due the involvement of granulomas, it's plausible any permanent or long-term filler injected in heavy volumes intramuscularly could plausibly have some type of late onset risks.
However, keep in mind
PMMA in the penis is injected in 10-20 cc's/mL's at a time, and seldom (if ever) exceeding 100 cc's/mL's in total over multiple rounds, all injected inter-dermally (not inter-muscularly). Also, granulomas in this regard are exceedingly rare and typically much easier to manage or resolve because of how localized it is (versus having a foreign material injected in hundreds of cc's/mL's in different areas of the body, like the buttocks, etc.).
I make this clear because
it does not have the same parameters as the aforementioned study, with significantly less volume, not silicone related, and skin injections (not muscle).
In a nutshell, I haven't seen a report, study, or former patient who has had strictly
PMMA enhancement of the penis show any adverse sexual and/or life impacting events, and I've been monitoring the
PMMA bit since nearly the inception of this site. It should be noted, however, no procedure is without risk. If you are highly risk-averse, you may want to consider
Hyaluronic Acid (
HA) alternatively. That said, I've had
PMMA in me (through
Avanti Derma in fact), with the next month marking 13 years post-op of my first appointment, with no complication to date.
You just have to weigh the pros & cons of what is known.
