What i don\'t understand : why is the bovine collagen carrier absorbed ?
Or more specifically : suppose you don\'t get an allergic / immune system response to the collagen, why is it still absorbed ?
Collagen are quite strong fibers, they don\'t just \"dissolve\". Your own collagen doesn\'t dissolve either, it stays for years in your body, ie. in scar tissue (very visible) but also in the dermis, in ligaments, tendons, ... (it isn\'t replaced as far as I know).
Or doesn\'t it ? Is your own collagen constantly broken down and replaced by new collagen ? So that the initial + extra collagen you inject, will after a certain time be broken down, and only replaced by the initial amount of collagen ?
Would it be possible to keep the injected collagen in place, even without
PMMA ? Ie. by injecting more complex collagen-based structures, that cannot be absorbed but don\'t create foreign body reactions either, instead of
PMMA spheres ?
Or would it be possible to increase the body\'s own collagen production, ie. by making a culture of your own body\'s fibroblasts and injecting them, so they produce more collagen then normally in the injected location ?
As far as I understand, by injecting
PMMA spheres into your dermis, you essentially create scar tissue around it.
Would it be possible to create scar tissue with something less permanent then
PMMA spheres, so that this material is absorbed by the body in the long run, but the scar tissue that was formed around it remains ?
That would totally remove the risk of foreign body response.
(just trying to understand what\'s going down beneath the skin, ...)