Hi Hoddle,
I thought about using the lower conc. of PMMA and thats why I have mentioned before it will be better to use these conc. in the final sessions, and I said if these steps (the usage of lowest conc. of pmma or what Mustang has mentioned :- Dr.C. can break the nodules with the cannula or even the usage of Kenalog injection) failed in correcting the minor aesthetic issues then the last option imo we can use these micro-droplets technique of Silikon1000 to fill these multiple small depressed areas and smoothen the outer rough surface of the collagen and I could explain why these micro-droplets tech. of S1000 is much better than the lower conc. of pmma :-
1- The advantage of these micro drops of S1000 (0.01-0.02 cc) the micro drop will stay exactly in the spot where you inject it i.e. you can control and decide almost exactly where you want the new collagen should form , so there will be no shifting of these drops and the fibroblast cells will form collagen and will fix them more in the same spots.
2- The Silikon1000 has an advantage it has no carrier fluid ( 100% pure silikon) in the other hand PMMA e.g. Metacrill the pmma beads are carried by carboxymethyle cellulose , and this carrier is so weak to carry these beads and thats why the beads clumps together in some injected areas (and it can happen even if it was a lower conc. used ---> small nodules can form esp. under thin skin e.g. at the circ. scar)
To explain it more as we know the nodules or the lumps from pmma injection will depend on the conc. of the beads in a specific area and sure the higher conc. of pmma e.g. 30% has a higher risk but I am sure even with the lowest conc. still there will be few beads e.g. 10-50 clump together and form a dense firm collagen i.e. nodules ---> rough outer surface of the new collagen. So the best way if we are looking for the best aesthetic end result is if we can (sure in the touch-ups after trying all the previous steps) separate these beads during injection and distribute them evenly (I am sure we all agree on that) but actually we cannot (impossible) do that (we can reduce these issues with the lower conc. but still we cannot prevent it).
In summary :- the roughness and irregularities can happen with PMMA injection :- 1) more with a higher conc., 2) also with the lower conc. clumping of the beads due to weak carrier can happen and 3) the carrier in e.g. Metacrill will be absorbed in the following hours post-injection so there can be some shift of these beads during this early period and come closer to each other ---> to form nodules or these beads can migrate in the early hrs to a non-intended spot.
There is another filler called \"Bioplastique\" which contain microspheres of solid silicon (injected with a carrier \"a PVP gel\") (almost the same idea with pmma products) but with a bigger size beads (around 40-100 microns ; too big to be engulfed by macrophages and too small to be encapsulated) than pmma. With this bioplastique filler you can get nodules and lumps ; the idea of this product came from Dr.Palanas 30 yrs ago he sliced a silastic sheet to many tiny pieces and then your body form collagen around them, then came Dr.Robert Ersek 1998 who had great experience with this filler :-
www.big-h.biz/Default.aspx?tabid=691&language=th-TH www.personique.com/bioplastique-photo-gallery.php
Dr.R. Ersek started to use Bioplastique in 1988 and he was the 1st doctor in the world who started to use a blunt micro-cannula \"bioplasty technique\" before the brazilian Dr.A.Nacul :-
www.clinicanacul.com.br/bioplastia.php?idioma=2
Sorry for this long post; but the reason I mentioned these things is the idea how we can control the trigger element (i.e. pmma bead or solid silicon microsphere) and fix them in the exact area point where we want them to be but unfortunately we cannot do that with solid inert microspheres carried in a fluid or gel, but in the other hand we can with the viscous pure Silikon 1000 micro-droplets tech. so we can control the site of the small new collagen to correct only the multiple small depressed areas.
Btw Silikon1000 is more inert to the body than pmma, and the new collagen formed around each micro drop of S1000 is softer the reason for that :- (each micro drop is separated from the other one by 3-5 mm distance i.e. no clumping so each collagen formed around each drop will have almost the same density like the next one) than the collagen formed around the pmma bead (some beads will be clumped together even if it was a lower conc.).
As I said before this step can be used after the trial of the lower conc. of pmma or other tech.s which Dr.C. have mentioned before.
@ Bigben , In regard of the danger of using pmma with Silikon1000 ?? First of all both these substances are inert, the other thing they are not injected at the same time, your own body\'s collagen will form and cover each bead of pmma and isolate them from the rest of the body and the new S1000 micro-droplet will be injected on the top of your own body tissue and not inside them (i.e. the collagen around the pmma beads) and it will be covered early with a new collagen, so the pmma beads wont be in direct contact with the Silikon1000 .