Dr. Samy Passy has replied to my e-mail (but most of you know that Dr. Samy owns Metacrill ???) :-
A) The result of Metacrill implant is related to the micro-spheres concentration: the more is the concentration, the more is the new tissue formation, so I use only 30% concentration.
New Plastic is an imitation of Metacrill, but it has not the same composition. Metacrill has EDTA that New plastic has not and other small differences that in conjunct makes a big difference.
The fabrication of New Plastic ceased some months ago.
I have no cases of lump formation in any area of Metacrill implant, because I do the implant in a cylindrical form.
I have asked him about EDTA :-
Q) What are the benefits of using EDTA \" ethylene diamine tetra-acetic acid \" in Metacrill ?? Does it only help in preventing infection and the bio-films ??
A) EDTA prevents infection and bio-films, but has another action that constitutes a secret of Metacrill, as I can not say it to you.
Q) I have also asked Prof. Lemperle about the different concentrations used by two different doctors (e.g. 10% and 30%), EDTA and its benefit and if it is used in Artefill and Artecoll ??
A) Theoretically, the beads in 10% are further apart and stimulate less tissue formation - but also less volume ! Only a third of what 30% do. So you have to inject it 3 x more often. I will discuss your question with Luis , with whom I fly to the
PMMA congress in Mexico City on Wednesday.
about EDTA :-
No, it may prevent clotting of the platelets - and they play no or little role in the encapsulation process of the microspheres.
It is known that EDTA from taking blood samples, where it prevents clotting. Maybe he uses it as a lubricant for the microspheres to be injected easier ???Biofilms and infections play no role in particulate injectables: there are too many macrophages around to
each possible bacterium....
Q) I have asked him again:- if he thinks that EDTA in Metacrill can help in preventing the beads from sticking to each other and becoming clustered together i.e. the beads will be better distributed and it will help the weak carrier (cellulose) in Metacrill in carrying the beads like what the stronger carrier (bovine collagen) in e.g. Artefill does ?? I.e. Cellulose+EDTA together have almost the same function as bovine collagen.
A) It could be true, we use Tween 20 or Tween 80 to cover the beads and make them suspended in the collagen - otherwise the beads will float on the collagen. EDTA may have the same effect. Inside the body, beads in cellulose clump anyway.
I just want to share these informations with all of you, I don\'t know if they are true or not, it could be that Dr. Samy is just bias for his product , I will try to get more information about that as much as I can.