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TOPIC: Intracovernosal injection of anti-LOX drugs?

Intracovernosal injection of anti-LOX drugs? 1 week 4 days ago #1308722611

I recently learned about how lysyl oxidase (LOX) can be inhibited with certain drugs to allow for faster remodeling (lengthening) of the tunica and I was wondering if this has been tried before in the form of intracavernosal injection. For those who don't know, the concern with inhibiting LOX is system effects, but it seems like this risk could be mitigated significantly just by administering an inhibitor directly into the cavernosa. It's an obvious solution, but I couldn't find anything on Google, so I thought I'd ask here.

If the idea of inhibiting LOX is new to anybody, here's a video for reference:


I'm aware of PXS-5505 as an oral anti-LOX drug, but that's it. If not injected, maybe this could be adapted for transdermal administration.

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Last edit: by MrDingDingDong.

Intracovernosal injection of anti-LOX drugs? 1 week 3 days ago #1308722626

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There's a Discord group created from a Reddit subforum. They'll be the first to use the PXS 5505, I think, in November. You can even buy it in that group. I think it's $1,000 for 12g.
If you want more information, follow Semtex on Reddit.
I'm not sure how risky or effective it is, so I'm not recommending anything.
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Intracovernosal injection of anti-LOX drugs? 1 week 2 days ago #1308722634

KV87 wrote: There's a Discord group created from a Reddit subforum. They'll be the first to use the PXS 5505, I think, in November. You can even buy it in that group. I think it's $1,000 for 12g.
If you want more information, follow Semtex on Reddit.
I'm not sure how risky or effective it is, so I'm not recommending anything.


Thank you! I'll check it out to get more info. Supposedly it's been shown to be safe when taken orally, but I don't see how there can't be side effects affecting the skin and other organs. There's no selectivity. That's my biggest concern. If you have myelofibrosis maybe it's a net positive, but if you're healthy?

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