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TOPIC: Comparison of Dermal Fillers used in Girth Enhancement

Comparison of Dermal Fillers used in Girth Enhancement 1 month 4 days ago #1308697854

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Comparison of Dermal Fillers used in Girth Enhancement 1 month 1 day ago #1308697902

A good summary except I dont accept that good HA fillers last 12 months or less. I have been using them for over 6 yrs and have seen guys come back after nearly 3 years and have 50%+ of the increase remaining. Frequently we see guys 18/12 out who are 90% of their post injection size in most of the penis but notice the base is a little thinner. I think that happens over time with some retraction pushing the product down the shaft slightly.
Ellanse I have never seen go away yet. Have used it for nearly 4 yrs. But I have not seen the original guys I treated either. Subtle77 was a relatively early patient I treated nearly 3 yrs ago and his last post said he has not seen any decrease in size.
What ever you do, make sure it is safe. Google calibreclinic

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Comparison of Dermal Fillers used in Girth Enhancement 1 month 1 day ago #1308697906

Dr Oates wrote: A good summary except I dont accept that good HA fillers last 12 months or less. I have been using them for over 6 yrs and have seen guys come back after nearly 3 years and have 50%+ of the increase remaining. Frequently we see guys 18/12 out who are 90% of their post injection size in most of the penis but notice the base is a little thinner. I think that happens over time with some retraction pushing the product down the shaft slightly.
Ellanse I have never seen go away yet. Have used it for nearly 4 yrs. But I have not seen the original guys I treated either. Subtle77 was a relatively early patient I treated nearly 3 yrs ago and his last post said he has not seen any decrease in size.


Question:
What distinguishes brands of HA if they're all the same substance? On Juvaderm's website, it claims they have a "modified form" of HA, and Macrolane was described as a "non-animal" HA. If there are indeed distinctions between brands of HA, can one postulate this being the reason why some versions are less satisfactory (like in the case of Macrolane) versus some versions that are more successful (like the ones used by CALIBRE) ?

I trust both Avanti Derma and CALIBRE's observations, since they come from reputable Clinics with adequate sample sizes, but something must be missing that could reconcile or solve why we have two differing conclusions... and I wonder if the formulation of HA (i.e. brand) may play a significant role? Thoughts?
.

Skeptical One
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Comparison of Dermal Fillers used in Girth Enhancement 1 month 8 hours ago #1308697933

Question:
What distinguishes brands of HA if they're all the same substance? On Juvaderm's website, it claims they have a "modified form" of HA, and Macrolane was described as a "non-animal" HA. If there are indeed distinctions between brands of HA, can one postulate this being the reason why some versions are less satisfactory (like in the case of Macrolane) versus some versions that are more successful (like the ones used by CALIBRE) ?

I trust both Avanti Derma and CALIBRE's observations, since they come from reputable Clinics with adequate sample sizes, but something must be missing that could reconcile or solve why we have two differing conclusions... and I wonder if the formulation of HA (i.e. brand) may play a significant role? Thoughts?
.[/quote]

Hi Skeptical One,

As you have noticed I am back!

Different versions of HA? Like there are different types of steel. They come from different sources, are processed differently, have different additives. They design them for different uses. In the early days of HA (Hylaform) it was harvested from rooster combs! We had t ask if they had an allergy to chicken. Restylane was the next company and they had it synthesised by a bacteria (like lots of medications are made). That is where they came up with the term NASHA - Non Animal Stabilized Hyaluronic Acid. Are the EU only requires a company to show that their product is "Substantially similar" for a CE mark lost of companies started making their own. Some wanted the cheapest or quickest route to market and some worked to try and make the best product they could ( but everyone claims to be the latter, it make life much easier if every company could just tell you the truth - this product is rubbish, it will cause you lots of problems and ruin your business).

Then there is the cross linking. HA is a sugar that can be joined up in long strands. Some companies make long strand HA. Some short chain. Some mix. I think it depends on what technology they started using and they worked out what it gave them later. But non cross linked HA gets broken down very quickly. So the form chemical bonds between separate strands of HA using various chemicals ie 1,4-butanediol diglycidyl ether (BDDE). Other companies use other chemicals. they are nasty and need to be washed out. Probably some companies do this better than others. Newer companies and products are looking at better ways of doing this.

Within even 1 brand there is a range of products meant to be used in different places. They have more or less HA/ml, more or less cross linking, have long or short chains or a mix. Some include their 'special sauce ie' skin lightening properties. From there is starts getting complicated.

I have tried a number of different companies and versions of HA. I currently use Teosyal Ultimate. It would be great to get 100 guys and use a number of different HA's and follow them closely for a couple of years to see what is best. That is basically how we work out the best drug for a condition. But it is not easy to do with this, without a huge budget. Thats why you hear it costing millions of dollars to do drug trials and why drug companies charge a fortune for a drug that may only cost them a few cents to make ( plus drug companies mainly exist to pay huge salaries and bonuses to the CEO, MD, Board etc).

Back to work now!
What ever you do, make sure it is safe. Google calibreclinic

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